Selected GTS Scientific and Clinical Publications

1."Efficient Wideband Linear Arrays for Imaging and Therapy," P .G. Barthe and M. H. Slayton, in Proc. 1999 IEEE Ultrasonics Symposium, 1999, pp. 1249-1252.

2. “Ultrasound Therapy System and Ablation Results Utilizing Miniature Imaging/therapy Arrays,” P.G. Barthe, M.H. Slayton, P.M. Jaeger, I.R.S. Makin, L. A. Gallagher, T. D. Mast, M. M. Runk, and W. Faidi, Proc. IEEE Ultrasonics Symposium, 2004, pp. 17992-1795

3.“Miniaturized Ultrasound Arrays for Interstitial Ablation and Imaging,” Inder Makin, T. Douglas Mast, Waseem Faidi, Megan Runk, Peter Barthe, Michael Slayton, Ultrasound in Med. & Biol., 31.11 (2005): 1539–1550.

4.“Bulk Ablation of Soft Tissue with Intense Ultrasound: Modeling and Experiments,” T. Douglas Mast, Inder Makin, Waseem Faidi, Megan Runk, Peter Barthe, Michael Slayton,  J. Acoust. Soc. Am. 118. 4 (October 2005): 2715-2724.

5.“Conformal Bulk Ablation And Therapy Monitoring Using Intracorporeal Image-Treat Ultrasound Arrays,” Inder Makin, Waseem Faidi, T. Douglas Mast, Megan Runk, Michael Slayton, Peter Barthe, 4th Int. Symp. On Therapeutic Ultrasound, AIP Conference Proceedings, Volume 754, pp. 27-29 (2005).

6.“B-scan Imaging and Thermal Lesion Monitoring Using Miniaturized Dual-Functionality Ultrasound Arrays,” Inder Makin, T. Douglas Mast, Waseem Faidi, Megan Runk, Peter Barthe, Michael Slayton, in Proc. 2004 IEEE Ultrasonics Symposium, 1788-1791.

7.“Selective Creation of Thermal Injury Zones in the Superficial Musculoaponeurotic System Using Intense Ultrasound Therapy, A New Target for Noninvasive Facial Rejuvenation,” W. Matthew White, Inder Makin, Peter Barthe, Michael Slayton, Richard Gliklich, Archives Facial Plastic Surgery, (Jan 2007) 9 : 22-29, www.archfacial.com, ©2007 American Medical Association.

8.“Clinical Pilot Study of Intense Ultrasound Therapy to Deep Dermal Facial Skin and Subcutaneous Tissues,” Richard Gliklich, W. Matthew White, Michael Slayton, Peter Barthe, Inder Makin, Archives Facial Plastic Surgery, (Mar 2007) 9 : 88-95.

9.“Intense Ultrasound (IUS) in Dermatology – an in-vitro evaluation of a new approach for precise microsurgery of the skin,” H. J. Laubach, Inder Makin, Michael Slayton, Peter Barthe, D Manstein.

10.“Selective Transcutaneous Delivery of Energy to Facial Stem Subdermal Tissues Using the Ultrasound Therapy System,” W. Matthew White, Hans-Joachim Laubauch, Inder Makin, Michael Slayton, Peter Barthe, Richard Gliklich, American Society for Laser Medicine and Surgery (ASLMS)  (April 2006).

11.“Confined Thermal Damage with Intense Ultrasound (IUS),” Hans J. Laubach, Peter Barthe, Inder Makin, Michael Slayton, Dieter Manstein, American Society for Laser Medicine and Surgery (ASLMS), (April 2006).

12.“Creation of Micro-Ablative Thermal Regions Within the Deep Dermis by Intense Ultrasound (IUS): A New Tool for Nonablative Facial Rejuvenation,” W. Matthew White, Inder Makin, Michael Slayton, Peter Barthe, Richard Gliklich, Am Acad. of Dermatology, (February 2007).

13.“Clinical Pilot Study Utilizing Intense Ultrasound (IUS): A Novel Approach for the Transcutaneous Delivery of Energy to Facial Skin,” Richard Gliklich, W. Matthew White, Inder Makin, Michael Slayton, Peter Barthe; Clinical pilot study completed at Otolaryngology, Mass Eye and Ear Infirmary, Boston, MA, USA.

14.“Safety and Efficacy of Transcutaneous Ultrasound for Forehead, Cheek and Neck Tissue Tightening,” Murad Alam, Lucile White, Rania Majzoub, Nicolle Martin, Simon Yoo, American Society for Laser Medicine and Surgery (April, 2007).

15.“Treatment Of VX2 Tumors In Vivo Using Miniaturized Image Ablate Arrays” Mast, T. Douglas; Barthe, Peter G.; Makin, Inder Raj S.; Slayton, Michael H.; Karunakaran, Chandra P.; Alqadah, Amel F.; Burgess, Mark T.; Buell, Joseph F.; Rudich, Steven M., J Ultrasound Med 28:S29, March 2009.

16."Design of an Ultrasonic Hyperthermia Unit for Breast Treatment," X.Q. Lu, G.K. Svensson, J.L. Hansen, B.A. Bornstein, J.R. Harris, E.C. Burdette, M. Slayton, and P. Barthe, presented at the North American Hyperthermia Society 14th Annual Meeting, 1994.

17.P .G. Barthe and M.H. Slayton, "1.5-D Ultrasound Transducer Array Characterization," Proc. 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 1996.

18. P .G. Barthe and M.H. Slayton, "Characterization of 1.5-D Ultrasound Transducer Arrays," Proc. 1996 IEEE Ultrasonics Symposium, pp. 1489-1493.

Intellectual Property

Currently, GTS has greater than 100 issued, published and/or pending patents supporting its Intense Therapeutic Ultrasound (ITU).

GTS is uniquely positioned in a specialized part of the medical device industry: intense high frequency ultrasound therapy with ultrasound imaging and monitoring capabilities. The company relies on a combination of patents, trademarks, copyrights, trade secrets and other intellectual property laws, nondisclosure agreements and other measures to leverage and protect our proprietary technology, intellectual property rights and know-how.

We have created unique approaches to thermally treat specific parts of the tissue with intense ultrasound, while keeping thermal injury zones’ shape, depth and position with ultimate, clinically, relevant flexibility and precision. Where appropriate, our technology also combines ultrasonic high resolution imaging and monitoring capabilities to target desirable locations inside and/or on the surface of the target tissue to achieve our ultimate clinical goals.